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. Author manuscript; available in PMC: 2010 May 25.
Published in final edited form as: Cancer Chemother Pharmacol. 2008 Jun 28;63(4):681–689. doi: 10.1007/s00280-008-0785-8

Fig. 6.

Fig. 6

CDDO-Me induces apoptosis and overcome drug resistance in drug resistance ovarian cancer cells. A: CDDO-Me inhibits cell growth and induces apoptosis in OVCAR8 and OVCAR8TR ovarian cancer cells. OVCAR8TR cells were seeded at a density of 8000 cells per well in a 96-well plate for 24 h. The cells were then treated with 0.01 μM paclitaxel, 1 μM cisplatin, 0.3 μM CDDO-Me or combination of the two drugs for an additional 24 hours. The cells were lysed with 10% NP-40 and the M30-Apoptosense ELISA assay was performed as described in “Materials and Methods”. B: MTT assay of CDDO-Me together with paclitaxel or cisplatin overcome drug resistance in paclitaxel resistant OVCAR8TR or A2780cp70 cells.