Table 4.

Changing Stress Patterns and Risk of ≥ 8 Moderate/Severe Symptoms, Odds Ratios and 95% Confidence Intervals

		Risk of ≥8 moderate/severe symptoms vs. <8a
		8+ symptoms: n (%)		Unadjusted		Adjustedb
Stress pattern group	n (%)c	Cycle 1d	Cycle 2d	OR	95% CI	OR	95% CI
Low stress both cycles	148 (63)	7%	10%	1.0	Referent	1.0	Referent
High stress cycle 1, low stress cycle 2	38 (16)	29%	5%	3.3	[0.9-11.4]	2.7	[0.8-9.5]
Low stress cycle 1, high stress cycle 2	27 (11)	18%	22%	5.2	[1.4-20.1]	5.1	[1.4-18.2]
High stress both cycles	22 (9)	27%	50%	25.0	[6.1-102.5]	21.8	[5.3-90.0]

^aOdds ratios (ORs) for ≥8 moderate/severe symptoms were calculated across both cycles using mixed models.

^bAdjusted for age, education, passive and active smoking, and waist/height ratio.

^cNumber and percentage of participants in each stress group (i.e., low stress both cycles).

^dPercentage who reported ≥8 moderate/severe symptoms in each cycle within each stress group (i.e., low stress both cycles).