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The effect of frequent alcohol use on the rate of decline of CD4+ cell count to ≤200 cells/μl over 30 months was assessed in 130 participants who had a baseline CD4+ cell count >200 cells/μl. Frequent alcohol use over time (two or more alcoholic drinks/day) significantly increased the decline of CD4+ cell count to ≤200 cells/μl. From Cox analysis we calculated an HR = 2.91: 95% CI: 1.23–6.85, p = 0.015.
