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. Author manuscript; available in PMC: 2010 Sep 17.
Published in final edited form as: Sci Transl Med. 2010 Mar 17;2(23):23ra19. doi: 10.1126/scitranslmed.3000678

Fig. 6.

Fig. 6

Slit reduces vascular leak caused by multiple inflammatory stimuli through enhancing VE-cadherin at the cell surface. (A) Under normal conditions, alveolar capillaries are semipermeable. (B) Inflammatory stimuli cause a large release of cytokines, leading to internalization of VE-cadherin and disruption of barrier function. This results in vascular leak and accumulation of protein-rich edema fluid in the alveolar space. (C) Slit enhances vascular barrier function against multiple cytokines by enhancing VE-cadherin at the cell surface.