Table 4.
Genes up- or down-regulated in IPC patients compared to control patients at 1 hour into surgery (t = 1)
| Gene name | Gene symbol | Public ID | Fold change | P |
|---|---|---|---|---|
| Immediate early genes | ||||
| Early growth response 1 | EGR1 | AV733950 | 2.84 | 0.001 |
| Myc proto oncogene protein | MYC | NM_002467 | 2.58 | 0.038 |
| Cellular oncogene c-fos | FOS | BC004490 | 2.11 | 0.018 |
| Immediate early response 2 | IER2 | NM_004907 | 1.58 | 0.034 |
| Jun oncogene | JUN | BC002646 | 1.43 | 0.001 |
| Oxidative stress defence | ||||
| Catalase | CAT | AU147084 | 2.14 | 0.017 |
| Glutathione S-transferase theta 1 | GSTT1 | AL359937 | 2.69 | 0.025 |
| Sequestosome 1 | SQSTM1 | AW293441 | 2.04 | 0.018 |
| Chaperone/Survival | ||||
| DnaJ (Hsp40) homolog, subfamily B, member 6 | DNAJB6 | AF080569 | 1.45 | 0.042 |
| Heat shock 22 kDa protein 8 | HSPB8 | BF109740 | 1.83 | 0.001 |
| BCL2/adenovirus E1 B 19 kDa interacting protein 1 | BNIP1 | NM_013979 | 1.50 | 0.004 |
| BCL6 co-repressor | BCOR | AF317391 | 1.74 | 0.047 |
| Anti-apoptotic | ||||
| Caspase 8 | CASP8 | BF439983 | -2.00 | 0.045 |
| Caspase 7 | CASP7 | NM_001227 | -1.31 | 0.026 |
| Mitochondrial | ||||
| Uncoupling protein 3 | UCP3 | NM_003356 | 2.41 | 0.001 |
| Pyruvate dehydrogenase kinase 4 | PDK4 | AL832708 | 2.99 | 0.009 |
* A positive number indicates elevated expression (fold change) in skeletal muscle tissue of IPC-treated patient compared to skeletal muscle tissue of control patient. A negative number indicates decreased expression (fold change) in skeletal muscle tissue of IPC-treated patient compared to skeletal muscle tissue of control patient.