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. 2010 May 11;10:49. doi: 10.1186/1471-213X-10-49

Figure 7.

Figure 7

Domain-specific RNCR2-IRES-GFP fusion constructs selectively inhibit either amacrine or Müller glia differentiation. Dominant-negative RNCR2 constructs were electroporated in vivo at P0.5 and analyzed at P21. (A-B) Section immunohistochemistry reveals that RNCR2-5'-IRES-GFP overexpression led to an increase in amacrine cells (yellow arrowheads), (C-E) RNCR2-middle-IRES-GFP overexpression led to an increase in Müller glia (white arrowheads) and amacrine cells and RNCR2-3'-IRES-GFP overexpression led to an increase in Müller glia. (F) Each of the RNCR2-IRES-GFP domain-specific constructs showed an increase in INL cells compared to control **p < 0.003.