Table 1.
Autoantibody tests that are widely available and help diagnosis
| Specificity | Frequency | Disease specificity | Currently tested by |
|---|---|---|---|
| SLE | |||
| dsDNA | 50–80% | High | ELISA, Crithidia |
| Sm | 15% | High | ELISA, (DID) |
| Ribosomal P | 10% | High | ELISA |
| Scleroderma | |||
| Topo I | 15% | High | ELISA, (DID) |
| Centromere | 25% | Moderate | IF |
| RNA polymerase III (RNAP III) | 20% | High | ELISA |
| PM/DM | |||
| Jo-1 (his-tRNA) | 20% | High | ELISA (DID) |
| RA | |||
| CCP | 70% | Moderate | ELISA |
| Rheumatoid factor (RF) | 70% | Low | Laser nephelometry, ELISA, Latex agglutination |
| Sjögren’s syndrome | |||
| Ro/SS-A | 70% | Low | ELISA, (DID) |
| La/SS-B | 40% | Moderate | ELISA, (DID) |
| MCTD (Mixed Connective Tissue Disease) | |||
| U1RNP | 100% | Low | ELISA (DID) |
ELISA enzyme-linked immunosorbent assay, DID double immunodiffusion