Table 2.
Common specificities of autoantibodies based on the ANA pattern and diagnoses
| ANA pattern | Clinical diagnosis |
|||
|---|---|---|---|---|
| SLE | SSc | PM/DM | ||
| Nuclear | Homogeneous/peripheral | dsDNA histones | ||
| Speckled | Sm, U1RNP, Ro/SS-Aa, La/SS-B, RNA helicase A (RHA) | Topo I (Scl-70), RNAP III, U1RNP | U1RNP, Mi-2, Ku | |
| Discrete speckled | Centromere | |||
| Nucleolar | (Ribosomal P)b | U3RNP, Th, PM-Scl, (Topo I)c | PM-Scl | |
| Cytoplasmic | Diffuse | Ribosomal P | Jo-1 (histidyl tRNA synthetase), Other ARSd, SRP | |
| GWBs | Su/Ago2 | Su/Ago2 | Su/Ago2 | |
a
Some sera show only cytoplasmic staining or negative ANA
b
Always with cytoplasmic, which may not be reported
c
With nuclear staining
d
ARS: aminoacyl tRNA synthetases, PL-7 (threonyl), PL-12 (alanyl), EJ (glycyl), OJ (Isoleucyl), KS (asparaginyl)
Bold commercially available, nonbold research level, underlined disease marker antibodies