Table 1.
Haplotype and diplotype frequencies for PRNP codons 112,136, 141, 154, 171, 237 in diverse samples of U.S. sheep
| Allele frequency | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Codon haplotype or diplotype | Panel version | Breeds on panels | |||||||||||||||
| 136 154 171 |
112 136 141 154 171 237 |
Genbank accessiona | All USMARC sheep sequencedb | V1.1 V2.0 V2.4 |
V2.4 | Composite | Dorset | Rambouillet | Texel | Suffolk | Finnsheep | Romanov | Katahdin | All Dorper | Dorper | White Dorper | Navajo-Churro |
| (n = 953) | (n = 168) | (n = 96) | (n = 29) | (n = 18) | (n = 17) | (n = 18) | (n = 16) | (n = 19) | (n = 19) | (n = 15) | (n = 16) | (n = 8) | (n = 8) | (n = 1 | |||
| ARQ | MALRQL | AY907689 | 0.517 | 0.534 | 0.522 | 0.385 | 0.270 | 0.457 | 0.194 | 0.729 | 0.868 | 0.921 | 0.533 | 0.719 | 0.750 | 0.688 | 0.500 |
| ARQ | TALRQL | FJ404778 | 0.072 | 0.024 | 0.035 | 0.029 | -c | 0.014 | - | 0.021 | - | - | - | - | - | - | - |
| ARQ | MAFRQL | FJ404776 | 0.009 | 0.002 | - | - | 0.008 | - | - | - | - | - | - | - | - | - | - |
| ARQ | MAFRQP | FJ404776 | 0.001d | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| ARR | MALRRL | AY907691 | 0.288 | 0.357 | 0.359 | 0.534 | 0.694 | 0.441 | 0.444 | 0.250 | 0.105 | 0.053 | 0.467 | 0.156 | - | 0.313 | - |
| ARH | MALRHL | AY907683 | 0.017 | 0.027 | 0.042 | - | - | - | 0.250 | - | - | - | - | - | - | - | - |
| AHQ | MALHQL | AY909542 | 0.009 | 0.024 | 0.016 | - | 0.028 | 0.088 | 0.111 | - | - | - | - | - | - | - | - |
| VRQ | MVLRQL | AY907685 | 0.035 | 0.027 | 0.021 | 0.052 | - | - | - | - | 0.026 | 0.026 | - | 0.125 | 0.250 | - | - |
| ARK | MALRKL | EF189728 | 0.054 | 0.006 | 0.005 | - | - | - | - | - | - | - | - | - | - | - | 0.500 |
| TRQd | MTLRQLe | AJ567987 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| ARQ, ARQ | MALRQL, MALRQL | AY907689 | 0.300 | 0.333 | 0.333 | 0.172 | 0.056 | 0.235 | - | 0.313 | 0.737 | 0.842 | 0.200 | 0.500 | 0.500 | 0.500 | - |
| ARQ, ARQ | MALRQL, TALRQL | FJ404777 | 0.069 | 0.030 | 0.021 | 0.069 | - | - | - | 0.188 | - | - | - | - | - | - | - |
| ARQ, ARQ | TALRQL, TALRQL | FJ404778 | 0.014 | 0.006 | 0.010 | - | - | - | - | 0.063 | - | - | - | - | - | - | - |
| ARQ, ARQ | MALRQL, MAFRQL | EF189724 | 0.004 | 0.006 | - | - | 0.056 | - | - | - | - | - | - | - | - | - | - |
| ARQ, ARQ | MAFRQL, MAFRQL | naf | 0.001 | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| ARQ, ARQ | MALRQL, MAFRQP | na | 0.001d | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| ARQ, ARQ | MAFRQL, MAFRQP | FJ404776 | 0.008d | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| ARQ, ARQ | MAFRQP, MAFRQP | na | 0.001d | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| ARQ, ARQ | MAFRQL, TALRQL | na | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| ARQ, ARQ | MAFRQP, TALRQL | na | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| ARQ, ARR | MALRQL, MALRRL | AY907684 | 0.254 | 0.262 | 0.271 | 0.276 | 0.333 | 0.412 | 0.111 | 0.125 | 0.211 | 0.105 | 0.667 | 0.188 | - | 0.375 | - |
| ARQ, ARR | TALRQL, MALRRL | FJ404777 | 0.046 | 0.030 | 0.021 | - | - | 0.059 | - | 0.250 | - | - | - | - | - | - | - |
| ARQ, ARR | MAFRQL, MALRRL | na | 0.011 | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| ARQ, ARR | MAFRQP, MALRRL | na | 0.003d | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| ARQ, ARH | MALRQL, MALRHL | AY907693 | 0.015 | 0.024 | 0.042 | - | - | - | 0.222 | - | - | - | - | - | - | - | - |
| ARQ, ARH | TALRQL, MALRHL | na | 0.001 | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| ARQ, ARH | MAFRQL, MALRHL | na | 0.001 | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| ARQ, ARH | MAFRQP, MALRHL | na | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| ARQ, AHQ | MALRQL, MALHQL | AY907687 | 0.002 | 0.006 | 0.010 | - | - | - | 0.056 | - | - | - | - | - | - | - | - |
| ARQ, AHQ | TALRQL, MALHQL | na | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| ARQ, AHQ | MAFRQL, MALHQL | na | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| ARQ, AHQ | MAFRQP, MALHQL | na | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| ARQ, VRQ | MALRQL, MVLRQL | AY907690 | 0.029 | 0.042 | 0.031 | 0.034 | - | - | - | - | 0.053 | 0.053 | - | 0.250 | 0.500 | - | - |
| ARQ, VRQ | TALRQL, MVLRQL | FJ404777 | - | 0.006 | - | 0.034 | - | - | - | - | - | - | - | - | - | - | - |
| ARQ, VRQ | MAFRQL, MVLRQL | na | 0.001 | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| ARQ, VRQ | MAFRQP, MVLRQL | na | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| ARQ, ARK | MALRQL, MALRKL | EF189727 | 0.037 | 0.006 | 0.010 | - | - | - | - | - | - | - | - | - | - | - | 1.000 |
| ARQ, ARK | TALRQL, MALRKL | na | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| ARQ, ARK | MAFRQL, MALRKL | na | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| ARQ, ARK | MAFRQP, MALRKL | na | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| ARR, ARR | MALRRL, MALRRL | AY907691 | 0.103 | 0.185 | 0.188 | 0.379 | 0.500 | 0.176 | 0.222 | 0.063 | - | - | 0.133 | 0.063 | - | 0.125 | - |
| ARR, ARH | MALRRL, MALRHL | AY907681 | 0.005 | 0.018 | 0.021 | - | - | - | 0.167 | - | - | - | - | - | - | - | - |
| ARR, AHQ | MALRRL, MALHQL | AY907682 | 0.008 | 0.030 | 0.021 | - | 0.056 | 0.059 | 0.167 | - | - | - | - | - | - | - | - |
| ARR, VRQ | MALRRL, MVLRQL | AY907688 | 0.020 | 0.006 | 0.010 | 0.034 | 0.000 | - | - | - | - | - | - | - | - | - | - |
| ARR, ARK | MALRRL, MALRKL | EF189729 | 0.026 | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| ARH, ARH | MALRHL, MALRHL | AY907683 | 0.001 | 0.006 | 0.010 | - | - | - | 0.056 | - | - | - | - | - | - | - | - |
| ARH, AHQ | MALRHL, MALHQL | AY907692 | 0.001 | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| ARH, VRQ | MALRHL, MVLRQL | AY907694 | 0.001 | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| ARH, ARK | MALRHL, MALRKL | EF189726 | 0.007 | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| AHQ, AHQ | MALHQL, MALHQL | AY909542 | 0.001 | 0.006 | - | - | - | 0.059 | - | - | - | - | - | - | - | - | - |
| AHQ, VRQ | MALHQL, MVLRQL | AY907686 | 0.001 | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| AHQ, ARK | MALHQL, MALRKL | EF189725 | 0.004 | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| VRQ, VRQ | MVLRQL, MVLRQL | AY907685 | 0.004 | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| VRQ, ARK | MVLRQL, MALRKL | EF189722 | 0.008 | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| ARK, ARK | MALRKL, MALRKL | EF189728 | 0.012 | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
aGenBank accession numbers for sequences from control animals on MSCP27 with the relavant diplotype (where available).
bSheep born 1995 to 2007. Allele or genotype frequencies that add up to 0.999 or 1.001 are the result of rounding errors.
cNo minor alleles detected
dSheep with 237P allele are descendents of a single composite ram
eNot present in U.S. populations surveyed. GenBank accession number correspends to Billinis et al. 2004. J. Gen. Virol. 85, 547-554
fNot available