Table 2.
Crude and adjusted associations between blood lipids and variants by race/ethnicity - NHANES III (1991-1994)
| Genetic Variant | Non-Hispanic White | Non-Hispanic Black | Mexican American | SNP X Race/ethnicity | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| β (95% CI) | FDR-adjusted P value* | β (95% CI) | FDR-adjusted P value | β (95% CI) | FDR-adjusted P value | FDR-adjusted P value | |||||||
| Crude Analysis | |||||||||||||
| High-density lipoprotein cholesterol | |||||||||||||
| rs854560 (PON1) | -2.23 (-5.15,0.69) |
0.3589 | -0.58 (-2.81,1.65) |
0.869 | 3.59 (1.55,5.64) |
0.0308 | 0.2552 | ||||||
| Low-density lipoprotein cholesterol | |||||||||||||
| rs7412 (APOE) | -16.68 (-27.85,-5.50) |
0.1144 | -20.58 (-29.12,-12.04) |
<.0001 | -19.80 (-33.33,-6.28) |
0.066 | 0.8931 | ||||||
| Total serum cholesterol | |||||||||||||
| rs7412 (APOE) | -13.90 (-25.39,-2.41) |
0.1569 | -16.26 (-25.75,-6.77) |
0.0374 | -10.26 (-19.18,-1.33) |
0.2871 | 0.9227 | ||||||
| Triglycerides | |||||||||||||
| rs5918 (ITGB3) | 0.05 (-0.06,0.17) |
0.7294 | 0.14 (0.07,0.20) |
0.0066 | -0.05 (-0.17,0.06) |
0.613 | 0.4653 | ||||||
| Adjusted Analysis** | |||||||||||||
| High-density lipoprotein cholesterol | |||||||||||||
| rs854560 (PON1) | -1.53 (-4.11,1.06) |
0.5062 | -0.09 (-2.20,2.02) |
0.9733 | 3.21 (1.45,4.97) |
0.022 | 0.1535 | ||||||
| Low-density lipoprotein cholesterol | |||||||||||||
| rs7412 (APOE) | -16.87 (-27.94,-5.81) |
0.0968 | -22.52 (-30.01,-15.04) |
<.0001 | -21.47 (-31.32,-11.62) |
0.0022 | 0.9012 | ||||||
| rs429358 (APOE) | 8.26 (1.19,15.33) |
0.264 | 3.85 (-2.14,9.84) |
0.6169 | 10.54 (6.41,14.67) |
<.0001 | 0.9012 | ||||||
| rs1799983 (NOS3) | 3.05 (-2.41,8.52) |
0.5284 | 5.28 (-0.42,10.98) |
0.4103 | -4.56 (-7.63,-1.48) |
0.0396 | 0.9012 | ||||||
| Total serum cholesterol | |||||||||||||
| rs7412 (APOE) | -15.26 (-26.16,-4.36) |
0.0902 | -20.68 (-28.90,-12.47) |
<.0001 | -12.54 (-19.89,-5.20) |
0.0198 | 0.9724 | ||||||
| rs429358 (APOE) | 9.82 (2.96,16.69) |
0.0902 | 4.35 (-2.30,11.01) |
0.6839 | 11.18 (7.11,15.25) |
<.0001 | 0.9724 | ||||||
| Triglycerides | |||||||||||||
| rs5918 (ITGB3) | 0.02 (-0.07,0.11) |
0.8985 | 0.14 (0.09,0.19) |
<.0001 | -0.01 (-0.14,0.11) |
0.8962 | 0.4419 | ||||||
β, beta coefficient; CI, confidence interval; FDR, false discovery rate
*P-value was based on Satterthwaite-adjusted F test and adjusted for multiple comparisons using false discovery rate within each race/ethnicity group.
**Adjusted for age, sex, education, body mass index, smoking status, alcohol intake, physical activity, dietary fat intake.