Figure 3. Gβ5 ablation potentiates GABA_B–dependent behavior.

a) Open–field locomotor activity of wild–type (WT, n=7) and Gβ5^–/– (n = 5) mice following administration of increasing baclofen doses (1, 3, 5, 10 mg/kg, s.c.). Activity was monitored for 3 hr after baclofen injection and then normalized to the activity of saline–treated controls of the same genotype. Basal locomotor activities of saline–treated controls were: 109±11 and 980±53 meters traveled per 3 hr session for wild–type and Gβ5^–/– mice, respectively. b) The effect of 10 mg/kg baclofen on motor activity as a function of time. Symbols: *, P<0.01 vs. control. Error bars are s.e.m. Mice were used in accordance with the protocols approved by the Animal Care and Use Committee at the University of Minnesota.