Table 1.
Secular changes in clinical characteristics of the bladder cancer population
| SEER 13 | SEER 17 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Year of Diagnosis | p - value | Year of Diagnosis | p - value | |||||||||
| 1993 | 1994 | 1995 | 1996 | 1997 | 1998 | 1999 | 2000 | 2001 | 2002 | |||
| Patients | 1745 | 1807 | 1769 | 1853 | 1759 | 1907 | 1943 | 3954 | 4103 | 4140 | ||
| Age (mean) | < 0.01 | 0.27 | ||||||||||
| 77.0 | 76.9 | 77.1 | 77.6 | 77.4 | 77.7 | 77.7 | 77.9 | 77.9 | 78.1 | |||
| Age (%) | < 0.01 | 0.69 | ||||||||||
| 65–69 | 16.8 | 16.8 | 18.0 | 15.4 | 14.0 | 13.5 | 13.8 | 13.6 | 13.2 | 12.6 | ||
| 70–74 | 26.2 | 26.8 | 25.3 | 23.5 | 27.2 | 23.9 | 25.4 | 23.2 | 24.0 | 23.3 | ||
| 75–79 | 24.6 | 25.3 | 24.1 | 26.2 | 25.9 | 27.8 | 25.9 | 26.9 | 25.9 | 26.1 | ||
| 80–84 | 19.3 | 17.9 | 18.4 | 17.9 | 18.3 | 19.7 | 18.3 | 20.5 | 20.3 | 21.5 | ||
| 85+ | 13.1 | 13.2 | 14.2 | 17.0 | 14.6 | 15.1 | 16.6 | 15.8 | 16.6 | 16.5 | ||
| Female (%) | 0.81 | 0.08 | ||||||||||
| 25.9 | 26.1 | 27.7 | 26.3 | 25.4 | 26.0 | 25.8 | 26.5 | 24.7 | 24.6 | |||
| Race (%) | 0.10 | 0.04 | ||||||||||
| White | 94.7 | 94.7 | 94.6 | 94.4 | 93.4 | 94.1 | 92.6 | 94.9 | 93.8 | 93.3 | ||
| Black | 3.0 | 3.1 | 2.6 | 2.8 | 3.8 | 2.8 | 4.1 | 2.7 | 3.0 | 3.2 | ||
| Other | 2.3 | 2.2 | 2.8 | 2.8 | 2.8 | 3.1 | 3.3 | 2.4 | 3.2 | 3.5 | ||
| Socio-economic status (%) | 0.55 | 0.64 | ||||||||||
| Low | 30.7 | 32.2 | 30.5 | 31.3 | 30.9 | 31.0 | 29.4 | 35.2 | 35.1 | 34.8 | ||
| Medium | 34.8 | 33.4 | 36.7 | 33.9 | 33.1 | 33.8 | 34.6 | 31.8 | 33.1 | 33.0 | ||
| High | 34.5 | 34.4 | 32.8 | 34.8 | 36.0 | 35.2 | 36.0 | 33.0 | 31.8 | 32.2 | ||
| Comorbidity (%) | 0.14 | 0.91 | ||||||||||
| 0 | 70.0 | 69.3 | 69.2 | 69.0 | 67.4 | 66.7 | 65.3 | 62.3 | 62.0 | 62.2 | ||
| 1 | 19.3 | 18.8 | 19.7 | 19.6 | 21.4 | 20.8 | 22.7 | 23.0 | 23.5 | 22.6 | ||
| 2 | 6.8 | 7.4 | 6.8 | 7.9 | 6.7 | 7.6 | 7.3 | 8.9 | 8.7 | 9.0 | ||
| 3+ | 3.9 | 4.5 | 4.3 | 3.5 | 4.5 | 4.9 | 4.7 | 5.8 | 5.8 | 6.2 | ||
| Tumor Stage | <0.01 | 0.10 | ||||||||||
| Ta | 54.1 | 54.4 | 56.3 | 58.2 | 59.0 | 57.8 | 53.1 | 53.8 | 52.0 | 54.6 | ||
| Tis | 7.6 | 6.1 | 5.9 | 8.5 | 8.6 | 8.1 | 7.9 | 6.6 | 7.6 | 6.6 | ||
| Ta, Tis, NOS | 11.6 | 12.7 | 12.5 | 9.1 | 8.0 | 10.1 | 13.5 | 14.6 | 13.8 | 13.4 | ||
| T1 | 26.7 | 26.8 | 25.3 | 24.2 | 24.4 | 24.0 | 25.5 | 25.0 | 26.6 | 25.4 | ||
| Tumor grade | <0.01 | 0.23 | ||||||||||
| 1 | 20.3 | 20.0 | 18.9 | 21.0 | 20.6 | 18.0 | 17.9 | 20.1 | 19.6 | 19.1 | ||
| 2 | 46.7 | 47.9 | 47.3 | 46.4 | 48.1 | 46.5 | 45.6 | 41.9 | 41.2 | 40.6 | ||
| 3 to 4 | 25.6 | 24.5 | 26.3 | 25.2 | 24.1 | 28.5 | 30.5 | 30.8 | 30.6 | 31.8 | ||
| Unknown | 7.4 | 7.6 | 7.5 | 7.4 | 7.2 | 7.0 | 6.0 | 7.2 | 8.6 | 8.5 | ||
| SEER Region | 0.10 | 0.26 | ||||||||||
| Seattle (Puget Sound) | 11.8 | 9.5 | 11.4 | 11.7 | 10.2 | 11.5 | 11.6 | 5.3 | 5.7 | 6.4 | ||
| Atlanta | 5.3 | 4.7 | 4.3 | 5.0 | 4.8 | 4.1 | 5.3 | 2.7 | 2.7 | 2.1 | ||
| Connecticut | 15.5 | 16.5 | 15.3 | 16.4 | 14.7 | 15.2 | 16.2 | 7.7 | 7.1 | 7.5 | ||
| Detroit | 17.8 | 17.8 | 18.8 | 17.0 | 19.4 | 17.3 | 17.8 | 8.7 | 8.6 | 8.3 | ||
| Hawaii | 1.2 | 1.1 | 1.6 | 1.5 | 1.2 | 2.0 | 1.2 | 0.9 | 0.9 | 1.2 | ||
| Iowa | 14.7 | 14.8 | 16.0 | 14.7 | 17.7 | 16.9 | 14.9 | 7.7 | 7.9 | 6.8 | ||
| New Mexico | 3.6 | 4.0 | 3.4 | 3.5 | 2.9 | 4.0 | 3.7 | 1.6 | 1.8 | 1.9 | ||
| Rural Georgia | 0.1 | 0.4 | 0.4 | 0.1 | 0.4 | 0.2 | 0.2 | 0.2 | 0.2 | 0.1 | ||
| Utah | 3.6 | 4.5 | 4.2 | 4.3 | 3.8 | 3.8 | 5.6 | 2.4 | 2.8 | 2.2 | ||
| California* | 26.4 | 26.7 | 24.6 | 25.8 | 24.9 | 25.0 | 23.5 | 30.5 | 29.1 | 29.6 | ||
| Kentucky | 7.4 | 7.5 | 8.1 | |||||||||
| Louisiana | 5.6 | 5.3 | 6.2 | |||||||||
| New Jersey | 19.3 | 20.4 | 19.6 | |||||||||
*
California includes the San Francisco, Los Angeles, and San Jose/Monterey registries in the SEER 13 data. In the SEER 17 data, California also includes greater California.