Fig. 1.

Stage-dependent pathogenesis: This figure illustrates the complexity of different pathogenic events (inflammation, synaptic loss, oxidative damage in addition to imaging, and CSF biomarkers) at different stages, showing that there is extensive tau and Aβ pathology prior to symptoms. Identifying plasma or CSF biomarkers specific for targeted pathway (inflammation, neurodegeneration) is important for the rapid development of treatments and early interventions