Figure 2. Phenotype of cloned stromal cells.
A) Proteoglycans from culture media of 3 selected stromal clones (CPD 22) were assayed for keratan sulfate-containing proteoglycan using monoclonal antibody J19 with (+) or without (−) pretreatment with keratanase. B) mRNA pools for keratocan (shaded) and ALDH (open) were determined by quantitative RT-PCR in primary keratocytes, clonal stromal cells (CPD 24), and passage-four fibroblasts. Values are normalized to keratocytes = 100. C) Primary keratocytes were immunostained for f-actin (green) and vinculin (red). D) Clonal stromal cells (CDP 50) were stained similarly to C. E) Fibroblasts, passage four, were stained similarly to C and D.
