Table 1.
Cumulative Risk of Adverse Obstetric Outcomes in Pregnant Women With Fibroids
| Fibroids | No Fibroids | P Value | Unadjusted OR (95% CI) | |
| Cesarean delivery | 48.8% (2098/4322) | 13.3% (22,989/173,052) | <.001 | 3.7 (3.5–3.9) |
| Malpresentation | 13.0% (466/3585) | 4.5% (5864/130,932) | <.001 | 2.9 (2.6–3.2) |
| Labor dystocia | 7.5% (260/3471) | 3.1% (4703/148,778) | <.001 | 2.4 (2.1–2.7) |
| Postpartum hemorrhage | 2.5% (87/3535) | 1.4% (2130/153,631) | <.001 | 1.8 (1.4–2.2) |
| Peripartum hysterectomy | 3.3% (18/554) | 0.2% (27/18,000) | <.001 | 13.4 (9.3–19.3) |
| Retained placenta | 1.4% (15/1069) | 0.6% (839/134,685) | .001 | 2.3 (1.3–3.7) |
| Chorio or endometriosis | 8.7% (78/893) | 8.2% (2149/26,090) | .63 | 1.06 (0.8–1.3) |
| IUGR | 11.2% (112/961) | 8.6% (3575/41,630) | <.001 | 1.4 (1.1–1.7) |
| Preterm labor | 16.1% (116/721) | 8.7% (1577/18,187) | <.001 | 1.9 (1.5–2.3) |
| Preterm delivery | 16.0% (183/1145) | 10.8% (3433/31,770) | <.001 | 1.5 (1.3–1.7) |
| Placenta previa | 1.4% (50/3608) | 0.6% (924/154,334) | <.001 | 2.3 (1.7–3.1) |
| First-trimester bleeding | 4.7% (120/2550) | 7.6% (1193/15,732) | <.001 | 0.6 (0.5–0.7) |
| Abruption | 3.0% (115/4159) | 0.9% (517/60,474) | <.001 | 3.2 (2.6–4.0) |
| PPROM | 9.9% (123/1247) | 13.0% (7319/56,418) | .003 | 0.8 (0.6–0.9) |
| PPROM or PROM | 6.2% (217/3512) | 12.2% (7425/60.661) | <.001 | 0.5 (0.4–0.6) |
OR, odds ratio; CI, confidence interval; IUGR, intrauterine growth restriction; PPROM, preterm premature rupture of membranes; PROM, premature rupture of membranes.
Reprinted from American Journal of Obstetrics & Gynecology, Vol. 198, PC Klatsky et al, “Fibroids and reproductive outcomes: a systematic literature review from conception to delivery,” pp. 357–366, Copyright 2008, with permission from Elsevier.7