FIG. 9.

SPICE simulations of a simplified tethered bilayer membrane with K⁺ ions as the only mobile species. (A) Applied potential ΔU, (B) ion concentration $\left[{\mathrm{K}}_{\mathrm{in}}^{+}\right]$ the submembrane space between the membrane and the solid substrate, (C) transmembrane potential ΔΦ_mem, and (D) net ionic current responses to the applied potential are shown as a function of time. Input parameters in the simulation are C_sr=5 μF, C_mem=0.67 μF, R_s=50 Ω, volume of the tether: 22 nL and P_K⁺=10⁻⁹ cm/s.