Table 2.

Distance measurements between the D1 and D2 lobes of GluK1–LBC.

Ligand	Distance average (Å) from MD					Distance (Å) from X-ray
	Chain ID	Ae	Be	Ce	De	Ae	Be	Ce	De
ATPOa	A					11	10.5	12.5	12.5
(S)-glutamateb	A	8.4	9	3	6.7	7.3	8.5	3	6.6
	B	8.5	9	3.1	6.6	7.2	8.7	2.9	6.6
Domoatec	A	9.5	9.3	3.9	6.8	6.9	9	6.7	9.2
	B	9.6	9.8	3.6	7.5	6.9	9	6.7	9.2
MSVIII-19d	A	9.1	9.1	3	6.7	7.6	8.9	3.3	6.6
	B	8.4	9	3	6.7	7.5	8.7	2.9	6.6
apo	A	7.7	9.6	3.3	7.1
	B	7.5	8.5	3.2	7
neoDH	A	8.6	8.8	3.6	6.9
	B	8.2	8.9	3.2	6.7
8-deoxy-neoDH	A	8	9.1	3	6.6
	B	8	8.8	3.4	6.7
8-epi-neoDH	A	9.7	8.9	3	6.7
	B	8.5	9.1	3.1	7
9-F-8-epi-neoDH	A	9.3	8.9	3	6.6
	B	8.2	8.9	3.1	6.7
9-deoxy-neoDH #1	A	8.5	8.7	4.2	7
	B	8.5	9.3	4.7	7
9-deoxy-neoDH #2	A	8.6	8.9	3	6.6
	B	8.3	8.9	4.1	6.9
9-epi-neoDH	A	8.3	8.8	3.2	6.7
	B	9.5	9.1	3	6.7
8,9-epi-neoDH	A	9.3	9	3.1	6.9
	B	8.7	9.2	3.4	7
4-epi-neoDH	A	9	8.8	3.1	6.8
	B	8	8.8	3.1	6.8
2,4-epi-neoDH	A	9.6	8.7	5.9	7.5
	B	8.8	8.8	6.7	8.7
DNQX	A	8.8	9.5	5.3	7.2
	B	11.8	11.2	9.2	11.2
LY466195	A	12	10.5	7.4	8.7
	B	10	9.2	5.5	6.6

^a1VSO (Hald et al., 2007).

^b1YCJ (Naur et al., 2005).

^c2PBW (Hald et al., 2007).

^dGPB (Frydenvang et al., 2009).

^eA: Ser721^Cα-Glu441^Cα, B: Glu738^Cα-Pro516^O, C: Asp687^N-Gly490^O, D: Ser689^Cα-Thr518^Cα.