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Serum pharmacokinetic parameters for anidulafungin, caspofungin, and micafungin in mice
| Drug | Dose (mg/kg) | Cmax (μg/ml) | AUC (mg·h/liter) | t1/2 (h) | Protein binding (%) |
|---|---|---|---|---|---|
| Anidulafungin | 80 | 60 | 1975 | 24 | 99 |
| 20 | 24 | 382 | 14.7 | ||
| 5 | 4.3 | 96 | 14.8 | ||
| Caspofungin | 80 | 58 | 667 | 8.75 | 97 |
| 20 | 26 | 345 | 6.87 | ||
| 5 | 18 | 164 | 6.18 | ||
| Micafungin | 80 | 53 | 1400 | 16 | 99.75 |
| 20 | 28 | 520 | 13 | ||
| 5 | 7 | 138 | 7.50 |
