TABLE 1.
Distribution of the 322 P. falciparum pfdhfr alleles from the Comoros Islands and Madagascar collected in 2006 and 2007
| Country and site | No. of isolates with the following pfdhfr haplotypea: |
||||
|---|---|---|---|---|---|
| NCSI | NCNI | NCSL | IRNI | IRNL | |
| Comoros Islands | |||||
| Anjouanb | 13 | 4 | 0 | 10 | 0 |
| Grande Comoreb | 16 | 4 | 0 | 19 | 3 |
| Mohélib | 16 | 4 | 0 | 15 | 0 |
| Total | 45 | 12 | 0 | 44 | 3 |
| Madagascar | |||||
| North | |||||
| Antsirananac | 0 | 0 | 1 | 2 | 0 |
| Antsohihyc | 1 | 0 | 0 | 0 | 0 |
| Andapac | 8 | 1 | 0 | 0 | 0 |
| Northwest | |||||
| Mahajungac | 7 | 0 | 0 | 3 | 0 |
| Maevatananab,c | 17 | 1 | 0 | 16 | 0 |
| West-central highlands, Tsiroanomandidyb,c | 5 | 1 | 0 | 17 | 0 |
| East-central highlands, Moramangab,c | 17 | 0 | 0 | 4 | 0 |
| South-central highlands, Ihosyb,c | 14 | 0 | 1 | 3 | 0 |
| Central west | |||||
| Miandrivazob,c | 16 | 2 | 0 | 16 | 0 |
| Morondavac | 8 | 1 | 3 | 0 | 0 |
| Central east, Toamasinac | 2 | 0 | 1 | 0 | 0 |
| Southwest | |||||
| Ejedab,c | 6 | 1 | 1 | 2 | 0 |
| Tuléarc | 3 | 0 | 1 | 0 | 0 |
| Southeast | |||||
| Manakarac | 0 | 0 | 1 | 0 | 0 |
| Farafanganac | 7 | 0 | 21 | 7 | 0 |
| Total | 111 | 7 | 30 | 70 | 0 |
a
The amino acids conferring resistance are shown in underlined boldface. The four letter codes show the amino acid residues at positions 51, 59, 108, and 164, respectively.
b
Collection year, 2006.
c
Collection year, 2007.