(A) Bactericidal activity of dexamethasone (▴), spermine (▵), dexamethasone-spermine (♦), and D2S (□) against P. aeruginosa PAO1. (B) Bactericidal activity of D2S (□) and LL-37 (•) against P. aeruginosa PAO1 and after 3 h of incubation in solution at pH 1.5 (○ and ▿ for D2S and LL-37, respectively), after 3 h of incubation in solution at pH 1.5 containing 0.5 mg/ml of porcine pepsin (♦ and ⊙ for D2S and LL-37, respectively), and in solution containing 2 mM CaCl2 (⋄ and ▪ for D2S and LL-37, respectively). Error bars represent standard deviations from four measurements.