TABLE 1.
Glycopeptide resistance after induction with subinhibitory concentrations of A40926, teicoplanin, or vancomycin
| Glycopeptide used for inductiona | MICb |
||
|---|---|---|---|
| A40926 | Teicoplanin | Vancomycin | |
| None | 4.0 | 0.9 | 20.0 |
| A40926 | 5.0 | 0.9 | 35.0 |
| Teicoplanin | 4.0 | 0.9 | 27.0 |
| Vancomycin | 4.0 | 0.9 | 20.0 |
a
Concentrations were as follows: A40926, 0.5 μg/ml; teicoplanin, 0.25 μg/ml; or vancomycin, 12 μg/ml.
b
MICs (μg/ml) are calculated from PAPs as those concentrations which inhibit the growth of 99.99% of the population. Results are the average of three independent experiments in which the standard deviation (SD) was less than 5%.