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(Top) HCV RNA kinetics in a patient who selected a V36C amino acid substitution on triple therapy with pegylated IFN-α2a, ribavirin, and telaprevir. The HCV RNA levels are expressed in log10 IU/ml. LLD, lower limit of detection. The circled dots represent the four time points at which quasispecies sequence analysis was performed. (Bottom) Dynamics of NS3 quasispecies populations after treatment withdrawal relative to the baseline.
