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Computationally predicted three-dimensional models of the V36 (wild-type, left) and V36C (resistant, right) NS3 protease variants complexed with telaprevir. The wild-type Val side chain is purple, whereas the Cys substitution is green. The four side chains located around Val at position 36 that make contact with Phe at position 43 are white, as the active-site Ser at position 139 and His at position 57. Telaprevir carbon atoms are light blue.
