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Target attainment results for doripenem at 500 mg every 8 h infused over 1 h and 4 h over a wide range of creatinine clearances observed in phase 1, 2, and 3 studies (○, 25% T>MIC; ▵, 30% T>MIC; +, 35% T>MIC). (A) One-hour infusion; (B) 4-hour infusion.
