TABLE 3.

Probability of PK/PD target attainment by renal function, duration of doripenem infusion, and MIC of pathogen

Renal function and dose regimena	MIC (μg/ml)b	% Probability of attaining PK/PD target (% fT>MIC)c
		25	30	35
Normal function to mild impairment (CLCR > 50 ml/min), 500 mg q8h
1-h infusion	1	99.58	97.24	91.84
	2	95.34	82.96	68.4
	4	66.46	43.1	25.3
4-h infusion	1	100	100	100
	2	100	100	100
	4	94.54	93.06	90.0
Moderate impairment, 250 mg q8h
Upper bound (CLCR = 50 ml/min)
1-h infusion	1	100	100	99.78
	2	99.8	98.06	91
	4	70.4	38.5	16.18
4-h infusion	1	100	100	100
	2	100	100	99.94
	4	73.2	63.18	49.48
Lower bound (CLCR = 30 ml/min)
1-h infusion	1	100	100	100
	2	100	99.96	99.84
	4	97.42	89.06	71.4
4-h infusion	1	100	100	100
	2	100	100	100
	4	94.46	91.28	85.54
Severe impairment, 250 mg q12h
Upper bound (CLCR = 29 ml/min)
1-h infusion	1	100	99.96	99.44
	2	99.7	96.5	86.98
	4	63.96	33.64	14.78
4-h infusion	1	100	100	100
	2	100	99.98	99.86
	4	82.7	64.92	40.84
Lower bound (CLCR = 10 ml/min)
1-h infusion	1	100	100	100
	2	100	100	100
	4	99.9	99.38	97.46
4-h infusion	1	100	100	100
	2	100	100	100
	4	99.78	99.54	98.66

^aAbbreviations: CL_CR, creatinine clearance; q8h, every 8 h; q12h, every 12 h.

^bNote that results are presented for MICs of 1 to 4 μg/ml because it is in this range of pathogen susceptibilities that the greatest amount of variation was seen in the target attainment rates.

^cProportion of patients with higher than PK/PD target, % fT>MIC.