TABLE 3.
Enzyme and replicon activity of SCH 900518 against mutations conferring resistance to boceprevira
| Parameter | Mutation(s) | Fold increaseb |
|---|---|---|
| K*i | V36M | 3 |
| V36A | 5 | |
| F43C | 8 | |
| T54A | 8 | |
| T54Sc | 3 | |
| R155K | 8 | |
| A156S | 100 | |
| A156T | 3,000 | |
| D168V | 1 | |
| V170A | 6 | |
| V36 M + R155K | 160 | |
| T54S + R155Kc | 58 | |
| EC50 | V36M | 8 |
| T54A | 11 | |
| R155K | 15 | |
| A156S | 70 | |
| A156T | >1,000 | |
| D168V | 1 | |
| V170A | 10 | |
| V36 M + R155K | 130 |
a
Data are the means of two or more experiments, unless indicated otherwise.
b
Fold increase in parameter value with SCH 900518 treatment relative to that for the wild type.
c
Data are from a single experiment.