TABLE 4.
Exploration of vancomycin dosing recommendation from 1,000 simulations for each patient data set and corresponding concentrations and AUC24/MIC profilea
| Recommended dosage (mg/kg) | % of simulated concnb |
Median AUCc (2.5th-97.5th percentile) | % with AUC24/MIC ratio of >400 | |||
|---|---|---|---|---|---|---|
| Trough |
Peak |
|||||
| <5 | >20 | <10 | >50 | |||
| 15 q24h | 38.9 | 2.3 | 0.02 | 7.0 | 377 (213-704) | 47.0 |
| 20 q24h | 27.2 | 7.4 | 0.005 | 26.4 | 505 (272-9700) | 77.1 |
| Dosage for AGA neonates | 5.2 | 9.3 | 0.02 | 7.7 | 565 (314-1224) | 91.1 |
| Dosage for AGA neonates applied to SGA infants | 0.8 | 32 | 0.01 | 14.8 | 673 (412-1355) | 98.1 |
| Dosage for SGA neonates | 7.0 | 8.3 | 0.01 | 5.8 | 676 (360-1355) | 94.1 |
| Dosage for SGA neonates applied to AGA infants | 18.6 | 2.1 | 0.1 | 2.0 | 505 (282-1079) | 73.9 |
a
A loading dose of 15 mg/kg was given for maintenance doses of less than 15 mg per dose. q24h, every 24 h.
b
Unit of concentration in mg/liter.
c
Unit of AUC in mg·h/liter.