TABLE 1.
Aminoglycoside resistance genes represented by probes on the resistance gene microarray
| Gene | Accession no. | Target(s) | Enzyme encoded | Reference |
|---|---|---|---|---|
| aac(3)-Ia | DQ370505 | Gentamicin | 3-N-Acetyltransferase | 29 |
| aac(3)-Ib | L06157 | Gentamicin | 3-N-Acetyltransferase | 13 |
| aac(3)-Id | AY458224 | Gentamicin | 3-N-Acetyltransferase | 13 |
| aac(3)-III | X13542 | Gentamicin | 3-N-Acetyltransferase | 1 |
| aac(3)-IVa | X01385 | Gentamicin | 3-N-Acetyltransferase | 8 |
| aac(3)-Vb | M97172 | Gentamicin | 3-N-Acetyltransferase | 24 |
| aac(6′)-I30 | AY289608 | Amikacin | 6′-N-Acetyltransferase | 22 |
| aac(6′)-Ib | AY103455 | Amikacin, kanamycin | 6′-N-Acetyltransferase | 13 |
| aac(6′)-IIa | AY123251 | Gentamicin | 6′-N-Acetyltransferase | 22 |
| aac(6′)-Ia | M18967 | Amikacin, kanamycin | 6′-N-Acetyltransferase | 28 |
| aacC1 | U04610 | Gentamicin | 3-N-Acetyltransferase | 13 |
| aacC2 | S68058 | Gentamicin | 3-N-Acetyltransferase | 32 |
| aacCA5 | AY463797 | Gentamicin, kanamycin, amikacin | 3-N-Acetyltransferase | 22 |
| aadA1 | EF422367 | Streptomycin | 3″-Adenylyltransferase | 32 |
| aadA2 | AF071555 | Streptomycin | 3″-Adenylyltransferase | 5 |
| aadA21 | AY171244 | Streptomycin | 3″-Adenylyltransferase | 22 |
| aadA5 | AB126604 | Streptomycin | 3″-Adenylyltransferase | 22 |
| aadA7 | AY458224 | Streptomycin | 3″-Adenylyltransferase | 12 |
| aadB | AY204504 | Gentamicin, kanamycin | 2″-Adenylyltransferase | 13 |
| aadE | AF516335 | Streptomycin | 6-Adenylyltransferase | 13 |
| aph(3)-Ia | V00359 | Kanamycin | 3′-Phosphotransferase | 6 |
| aph(3)-IIa | V00618 | Kanamycin | 3′-Phosphotransferase | 6 |
| aph4 | V01499 | Hygromycin B | Aminocyclitol phosphotransferase | 20 |
| aphA-3 | AF516335 | Kanamycin | 3′-Phosphotransferase | 13 |
| aphA7 | AY509004 | Kanamycin | 3′-Phosphotransferase | 22 |
| aphD | Y00459 | Streptomycin | 6-Phosphotransferase | 10 |
| aphE | X53527 | Streptomycin | 3″-Phosphotransferase | 30 |
| aphIII | V01547 | Kanamycin | 3′-Phosphotransferase | 17 |
| strA | AY055428 | Streptomycin | 6-Phosphotransferase | 3 |
| strB | NC_005014 | Streptomycin | 6-Phosphotransferase | 3 |