TABLE 3.
Testing of 2009 A(H1N1) and animal virus susceptibility to favipiravir in plaque reduction assay with MDCK cellsb
| Strain designation | Subtype | Adamantane phenotype | M2 mutations | Oseltamivir phenotype | Zanamivir phenotype | NA mutationa | Favipiravir EC50 ± SD (μM) |
|---|---|---|---|---|---|---|---|
| A/South Dakota/03/2008 | swH1N1 | S | S | S | 0.83 ± 0.06 | ||
| A/Texas/14/2008 | swH1N1 | S | V27T, V28D | S | S | 4.52 ± 0.06 | |
| A/Michigan/09/2007 | swH1N2 | S | V27I, V28D | S | S | 2.23 ± 0.12 | |
| A/Mexico/4604/2009 | H1N1pdm | R | V28I, S31N | S | S | 1.21 ± 0.06 | |
| A/California/04/2009 | H1N1pdm | R | V28I, S31N | S | S | 1.97 ± 0.06 | |
| A/California/05/2009 | H1N1pdm | R | V28I, S31N | S | S | 0.83 ± 0.06 | |
| A/California/07/2009 | H1N1pdm | R | V28I, S31N | S | S | 1.40 ± 0.06 | |
| A/New York/18/2009 | H1N1pdm | R | V28I, S31N | S | S | 0.89 ± 0.06 | |
| A/Illinois/10/2009 | H1N1pdm | R | V28I, S31N | R | S | H274Y | 22.48 ± 0.06 |
| A/Washington/29/2009 | H1N1pdm | R | V28I, S31N | R | S | H274Y | 6.62 ± 0.12 |
| A/Ann Arbor/6/1960 | H2N2 | S | S | S | 0.38 ± 0.12 | ||
| A/turkey/Minnesota/833/1980 | H4N2 | S | S | S | 0.96 ± 0.06 | ||
| A/turkey/Minnesota/833/1980 | H4N2 | S | S | R | E119G | 0.89 ± 0.06 | |
| A/duck/Vietnam/NCVD93/2007 clade 2.3.4 | H5N1 | S | S | S | 1.59 ± 0.06 | ||
| A/duck/Vietnam/NCVD94/2007 clade 2.3.4 | H5N1 | S | R | R | I117V | 3.38 ± 0.06 | |
| A/chicken/Vietnam/NCVD103/2007 clade 2.3.4 | H5N1 | S | S | S | I222T | 1.27 ± 0.12 | |
| A/Vietnam/1203/2004 clade 1 | H5N1 | R | L26I, S31N | S | S | 5.22 ± 0.06 | |
| A/Vietnam/HN30408/2005 H274Y clade 1 | H5N1 | R | L26I, S31N | R | S | H274Y | 4.14 ± 0.06 |
| A/Vietnam/HN30408/2005 N294S clade 1 | H5N1 | R | L26I, S31N | R | R | N294S | 1.341 ± 0.06 |
| A/turkey/VA/4529/2002 | H7N2 | S | S | S | 1.53 ± 0.12 | ||
| A/New York/107/2003 | H7N2 | R | V28A, S31N | S | S | 10.2 ± 0.44 |
a
N2 amino acid numbering.
b
S, sensitive; R, resistant, based on surveillance criteria (50). Values reported represent means of experiments performed in duplicate on three separate occasions ± standard deviations. Boldface type, established resistance-conferring mutation.