Effect of echinocandins on M. mycetomatis and A. fumigatus. (A) M. mycetomatis growth control. (B) M. mycetomatis exposed to 1 mg/liter CAS. (C) A. fumigatus growth control. (D) A. fumigatus exposed to 1 mg/liter CAS. (E) M. mycetomatis β-1,3-d-glucan concentration of strain Mm55 as determined by the aniline blue assay. β-1,3-d-Glucan concentrations were corrected to the number of viable cells with the XTT assay by the following formula: (amount of beta-glucan measured) × (number of viable cells in tested well/number of viable cells in growth control). Each point represents the mean β-1,3-d-glucan concentration with the standard deviation. (F) A. fumigatus β-1,3-d-glucan concentration as determined by the aniline blue assay. β-1,3-d-Glucan concentrations were corrected to the number of viable cells with the XTT assay. Each point represents the mean β-1,3-d-glucan concentration with the standard deviation. CAS, caspofungin; MICA, micafungin; ANI, anidulafungin; GC, growth control.