TABLE 1.
MICs of various aminoglycosides for amikacin-susceptible (IFM 10152/pNV19), amikacin-resistant (IFM 10580), and transformed [IFM 10152/pNV19- 16S(1408G)] N. farcinica strains
| Aminoglycoside | MIC (μg/ml)a for strain: |
|||
|---|---|---|---|---|
| IFM 10152b (day 3) | IFM 10580 (day 3) | IFM 10152/pNV19-16S(1408G) |
||
| Day 3 | Day 5 | |||
| Amikacin | <1 | >1,024 | 64 | >1,024 |
| Kanamycin | 256 | >1,024 | >1,024 | >1,024 |
| Neomycin | 16 | >1,024 | >1,024 | >1,024 |
| Streptomycin | 64 | 128 | 64 | 128 |
| Arbekacin | <1 | >1,024 | 2 | >1,024 |
| Gentamicin | 64 | >1,024 | 256 | >1,024 |
| Tobramycin | 32 | >1,024 | 64 | >1,024 |
| Paromomycin | 8 | >1,024 | >1,024 | >1,024 |
| Apramycin | 32 | >1,024 | 64 | 256 |
| Isepamicin | <1 | >1,024 | 16 | 128 |
| Hygromycin B | 32 | 32 | 32 | 32 |
| Fortimicin | 8 | >1,024 | 16 | >1,024 |
| Ribostamycin | 256 | >1,024 | >1,024 | >1,024 |
| Netilmicin | <1 | >1,024 | 4 | 32 |
a
All transformed cells were cultured in the presence of each aminoglycosides for 3 or 5 days.
b
The susceptible strain was transformed with the empty vector.