TABLE 1.
Pharmacokinetic parameters of SBECD in 14 patients with end-stage renal failure on renal replacement therapy
| Pharmacokinetic parameter | Value (mean ± SD) for SBECD aftera: |
||
|---|---|---|---|
| Genius dialysis | Hemodialysis | Hemodiafiltration | |
| Parameters based on plasma values | |||
| T1/2 (h) | 2.6 ± 0.6 | 2.4 ± 0.9 | 2.0 ± 0.6** |
| Cmaxb (mg/liter) | 254.6 ± 56.7 | 269.9 ± 41.1 | 245.8 ± 38.3 |
| Vz (liter) | 20.1 ± 7.4 | 18.8 ± 6.9 | 19.0 ± 6.0 |
| CLtot (liter/h) | 5.4 ± 1.1 | 5.5 ± 0.9 | 6.7 ± 1.5** |
| CLextra,plasma-based,2h (liter/h)c | 3.9 ± 1.2 | 4.5 ± 1.5 | 5.8 ± 0.4* |
| CLextra,plasma-based,3h (liter/h)c | 3.9 ± 0.9 | 4.6 ± 1.7 | 5.9 ± 0.8**/+ |
| Atotal (%) | 74.9 ± 7.6 | 79.4 ± 9.5 | 84.2 ± 7.8*** |
| Atotal (mg) | 4,631.7 ± 907.6 | 4,929.8 ± 854.3* | 5,332.4 ± 1,180.1*** |
| Parameters based on dialysate values | |||
| CLextra,dialysate-based (liter/h) | 5.0 ± 2.0 | 4.7 ± 1.6 | 5.3 ± 1.6 |
| Aextra (%) | 69.0 ± 16.0 | 66.1 ± 13.1 | 66.9 ± 19.2 |
| Adialysate (mg) | 4,432.6 ± 1,861.1 | 4,228.0 ± 1,511.7 | 4,254.9 ± 1,472.9 |
a
Values for the patients treated by Genius dialysis that are significantly different from the values for patients treated by hemodialysis or hemodiafiltration are indicated as follows: *, P < 0.05; **, P < 0.01; ***, P < 0.001. Values for the patients treated by hemodialysis that are significantly different (P < 0.05) from the values for patients treated by hemodiafiltration are indicated (+).
b
Cmax, maximum concentration of drug in serum.
c
n = 11 for 2-h clearance (CL). n = 10 for 3-h CL.