TABLE 2.

Activity of BAL30072 against strains with identified β-lactamases as the sole determinant of β-lactam resistance

Organism	Enzyme present	MIC (μg/ml)
		BAL30072	ATM	MEM	IPM
E. coli HB101(pAT268)	TEM-5	32	32	≤0.06	0.25
E. coli K802N(pAT251)	TEM-3	>32	>32	16	32
E. coli CF102	TEM-3	4	32	≤0.06	0.5
K. pneumoniae 1357E	TEM-10	4	>32	≤0.06	0.5
E. coli A	CTX-M 15	0.125	>32	0.125	0.25
K. pneumoniae 26768WU	SHV-5	>32	>32	≤0.06	1
K. oxytoca 1028E	K1	0.5	>32	0.125	0.5
P. aeruginosa 1973E	PSE-1, class C	4	8	4	2
P. aeruginosa 1937E	PSE-4, class C	2	4	1	2
S. marcescens S6	SME-1, AmpC	≤0.06	16	32	>32
E. coli nmcA	NMCA	1	>32	>32	>32
K. pneumoniae CRE	KPC-2	≤0.06	>32	>32	>32
K. pneumoniae YC	KPC-2,TEM-1, SHV-2	>32	>32	>32	>32
A. baumannii HPA 74510	IMP-4	0.25	32	32	16
P. aeruginosa HPA101-1477	IMP-1	2	8	>32	>32
P. aeruginosa HPA10586	VIM-1	2	16	>32	>32
P. aeruginosa HPA996	VIM-2	1	8	32	>32
P. rettgeri J96	IMP-1	0.125	2	>32	>32
S. maltophilia B715	L1, L2	0.25	32	>32	>32
E. cloacae 908R	AmpC	4	>32	0.125	1
E. coli “Libyien”	CMY-2	4	16	0.125	1
P. aeruginosa BA	Class C	0.5	4	1	1
P. aeruginosa 18S/H	Class C	2	>32	2	4
S. marcescens 1T9	Class C	1	8	0.125	1
A. baumannii HPA 327009	OXA-25	4	16	>32	>32
A. baumannii HPA 4737	OXA-26	8	32	>32	>32
A. baumannii HPA I-16	OXA-27	0.5	32	>32	>32