TABLE 3.
Effects of outer membrane protein and efflux pump disruptions on the activity of BAL30072 against P. aeruginosa
| Strain | Disruption | Source or reference | MIC (μg/ml) |
|||||
|---|---|---|---|---|---|---|---|---|
| BAL30072 | Meropenem | Imipenem | Ceftazidime | Ciprofloxacin | Polymyxin B | |||
| B4 | None | Basilea | 0.5 | ≤0.06 | 1 | 4 | 2 | 2 |
| C2 | ΔoprD | Basilea | 0.25 | 1 | 32 | 2 | 8 | 4 |
| PAO1 | None | 2 | 2 | 1 | 2 | 1 | 0.25 | 8 |
| PAO238 | Δ(mexAB-oprM) Δ(mexCD-oprJ) | 2 | 0.125 | 0.5 | 2 | 0.5 | ≤0.06 | 8 |
| PAO253 | Overproduces (MexEF-OprN), Δ(mexAB-oprM) | 8 | 0.5 | 0.5 | 4 | 0.25 | 1 | 4 |
| PAO267 | ΔamrR (ΔmexZ) Δ(mexAB-oprM) | 8 | ≤0.06 | 0.125 | 1 | 0.5 | ≤0.06 | 8 |
| PAO750 | Δ(mexAB-oprM) Δ(mexCD-oprJ) Δ(mexEF-oprN) Δ(mexJK) Δ(mexXY) ΔopmH ΔpscC | 28 | ≤0.06 | 0.5 | 2 | 0.5 | ≤0.06 | 8 |
| 860 | ΔfpvA ΔfpvB ΔfptA ΔpirA | Basilea | 1 | 1 | Not tested | Not tested | Not tested | Not tested |
| (560546)9 M.P. | ΔfpvA | Basilea | 1 | 2 | Not tested | Not tested | Not tested | Not tested |
| 134 | ΔpfeA | Basilea | 1 | 1 | ||||
| BA | None | Basilea | 1 | 1 | 1 | 2 | 0.25 | 4 |
| BA(C2-107) | Selected with 20 μg/ml BAL30072 | This study | 8 | 2 | 1 | 2 | 0.5 | 4 |
| BA(C1-106) | Selected with 25 μg/ml BAL30072 | This study | 16 | 1 | 1 | 16 | 0.5 | 2 |