TABLE 6.

Recovery of single-step resistant mutants

Strain	MIC (mg/liter)	Inoculum	Highest BAL30072 concn (mg/liter) at which colonies appeared	Incidence of colonies appearing at >4× MIC
				BAL30072	Meropenem
A. baumannii HPA74510	1	4.4 × 106	4	None recovered	Parent resistant
A. junii 15218	0.25	6.6 × 106	1	None recovered	None recovered
		4.9 × 108
E. cloacae S4741B	1	5.3 × 106	16	7 × 10−7	None recovered
E. cloacae S9639	4	4.6 × 106	8	None recovered	None recovered
		2.2 × 108
E. coli W3110	0.25	2.7 × 108	1	None recovered	None recovered
K. pneumoniae 1338665	4	2.4 × 106	4	None recovered	Parent resistant
		2.1 × 108	16
P. aeruginosa BA	1	2.8 × 106	2	None recovered	10−7
		2.5 × 108	32	2.1 × 10−6
P. aeruginosa 527	2	7.1 × 106	16	1.8 × 10−6	Parent resistant
		7.1 × 108	64	9.6 × 10−8
P. aeruginosa 621	0.125	4.7 × 106	2	2.5 × 10−6	10−5
		6.7 × 108	16	2.8 × 10−7
P. aeruginosa 860	4	8.5 × 106	32	7 × 10−7	10−5