TABLE 7.
Development of resistance during serial passage
| Strain | No. of passages required for MIC to rise above 4× original MIC |
||||
|---|---|---|---|---|---|
| BAL30072 | Meropenem | Imipenem | Cefepime | Ciprofloxacin | |
| A. baumannii HPA74510 | 6 | Parent resistant | 1 | Parent resistant | Parent resistant |
| A. junii 15218 | 20 | 9 | 17 | 14 | 12 |
| E. cloacae S4741B | 9 | 7 | 3 | 5 | 4 |
| E. cloacae S9639 | 8 | 9 | 9 | 4 | 8 |
| K. pneumoniae 1338665 | 9 | Parent resistant | 2 | Parent resistant | Parent resistant |
| P. aeruginosa 527 | 9 | 3 | Parent resistant | 1 | 3 |
| P. aeruginosa 621 | 5 | 2 | Parent resistant | Not tested | Not tested |
| P. aeruginosa BA | 5 | 3 | 4 | 2 | 2 |
| S. maltophilia 1AC736 | 4 | Parent resistant | Parent resistant | 1 | Parent resistant |