TABLE 3.

ST-246 Exposure summary

ST-246 dose group/ parameter (mean)	Value for:
	Day 1	Day 6	Day 21
250 mg/day
Mean Cmax (ng/ml)	985	1,212	1,101
Median Cmax (ng/ml)	984	1,065	954
SD	346	350	378
Cmax range (ng/ml)	518-1,430	907-1,970	835-1,910
Mean AUCtau (ng·h/ml)	9,101	11,892	10,083
Median AUCtau (ng·h/ml)	8,042	10,436	9,755
SD	3,492	4,389	2,843
AUCtau range (ng·h/ml)	5,136-14,443	6,932-20,846	6,257-14,511
t1/2 (h)	NRa	NR	18.8
400 mg/day
Mean Cmax (ng/ml)	1,392	1,298	1,457
Median Cmax (ng/ml)	1,300	1,330	1,635
SD	411	277	451
Cmax range (ng/ml)	755-2,050	778-1,700	742-1,870
Median AUCtau (ng·h/ml)	14,785	14,834	17,118
SD	3,626	4,708	5,534
Mean AUCtau (ng·h/ml)	13,146	15,432	16,182
AUCtau range (ng·h/ml)	7,291-16,641	8,777-21,980	7,040-23,143
t1/2 (h)	NR	NR	19.8
800 mg/day
Mean Cmax (ng/ml)	2,279	2,337	2,437
Median Cmax (ng/ml)	2,385	2,190	2,275
SD	395	437	496
Cmax range (ng/ml)	1,570-2,680	1,880-3,060	1,960-3,130
Median AUCtau (ng·h/ml)	20,269	21,387	22,526
SD	6,091	4,696	4,579
Mean AUCtau (ng·h/ml)	20,959	23,352	22,684
AUCtau range (ng·h/ml)	14,962-31,670	18,903-30,592	17,684-28,009
t1/2 (h)	NR	NR	20.7
Result for all dose groups
Tmax (h)	2.88-3.25	2.63-3.57	2.67-3.17

^aNR, not reported.