FIG. 2.

In vivo efficacy levels of DB745 and DB766 in the murine VL model. Compounds were given i.p. (A and C) or p.o. (B and D) once daily for 5 days to mice infected with L. donovani promastigotes. Results are presented as the percentage of reduction in liver parasitemia (LDU) versus untreated controls. Miltefosine given i.p. served as a positive control in all groups. Bars and error bars denote the means and standard deviations, respectively, of experimental groups containing four animals. *, P < 0.05, compared to untreated control; #, mice in this group received only four doses due to toxicity.