TABLE 3.

DB766 in vivo efficacy in the hamster VL model

Drug	Dose (mg/kg/day for 5 days)	% Inhibitiona in:
		Liver		Spleen		Bone marrow
		Mean	SD	Mean	SD	Mean	SD
DB766, p.o.	10	10	10	NDb	ND	ND	ND
	30	75	17	67	24	24	50
	50	76	21	74	29	70	22
	100	89	6	79	8	92	6
Miltefosine, p.o.	30	88	8	79	6	91	9

^aAll percent inhibition data are presented as the means and standard deviations of four replicate determinations in LDU.

^bND, not determined.