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Liver microsomal half-lives (t1/2) for AIAs
| Compound | Substrate concn (μM) | Liver microsomal t1/2 (min)a |
|||
|---|---|---|---|---|---|
| Human | Rat | Mouse | Hamster | ||
| DB745 | 0.1 | >120 | 80 | 15 | 75 |
| 1 | >120 | >120 | 47 | >120 | |
| 10 | >120 | >120 | >120 | >120 | |
| DB766 | 0.1 | >120 | 96 | 26 | 39 |
| 1 | >120 | >120 | >120 | >120 | |
| 10 | >120 | >120 | >120 | >120 | |
