TABLE 6.
Pharmacokinetic measurements of DB766 after single i.v. or p.o. administration in mice
| Parametera | Pharmacokinetic measurement of DB766 after indicated dose (μmol/kg) administration |
||
|---|---|---|---|
| 1.5 (1.0 mg salt/kg) i.v. | 7.5 (5.0 mg salt/kg) i.v. | 100 (70 mg salt/kg) p.o. | |
| AUC0-∞ (h · μM) | 2.53 | 9.53 | 13.2 |
| AUC_%Extrap (%) | 8 | 14 | 13 |
| Cmax (μM) | 1.09 | 10.41 | 1.76 |
| Tmax (h) | 0.0833 | 0.0833 | 1 |
| t1/2 (h) | 22 | 24 | 48 |
| CL (ml/min/kg)b | 9.9 | 13.1 | 13.2 |
| Vss (liter/kg)c | 14 | 15 | 54 |
| F (%)d | 10.4 | ||
a
Noncompartmental analysis by WinNonlin 5.0.1, 1/y weighting, linear up/log down.
b
Observed total body clearance; for p.o. administration, corrected with F.
c
Predicted steady-state volume of distribution for i.v. administration; predicted volume of distribution based on terminal phase.
d
Calculated based on the AUC at 7.5 μmol/kg i.v.