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NOAELs and MTDs of AIAs in female BALB/c mice treated p.o. or i.v. once a day for five consecutive days
| Compound | NOAEL (mg/kg/day) |
MTD (mg/kg/day) |
||
|---|---|---|---|---|
| p.o. | i.v. | p.o. | i.v. | |
| DB745 | 50 | 5 | Between 50 and 150 | 10 |
| DB766a | 50 | 20 | 100 | 30 |
Doses higher than 100 mg/kg/day were not tested due to limited aqueous solubility.
