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Robustness of the C. pneumoniae entry network. (A) Gene combination knockout. The network diameter was dramatically changed after a 6-gene knockdown. (B) A combination of genes significantly reduced C. pneumoniae (CPN) infectivity. Knockdown of six genes almost entirely ablated C. pneumoniae infectivity, as measured by C. pneumoniae 16S rRNA expression using real-time qRT-PCR as described in Materials and Methods.
