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. 2010 Apr 5;30(11):2799–2810. doi: 10.1128/MCB.00157-10

FIG. 6.

FIG. 6.

Capn4 knockdown ATDC5 cells exhibited reduced cyclin D1 mRNA expression. (A) Knockdown of Capn4 impaired TGF-β1-mediated cyclin D1 mRNA expression in ATDC5 cells. Cells were incubated with 1 ng/ml TGF-β1 for 0 and 2 h. (B) Knockdown of Capn4 impaired TGFβ1-mediated phosphorylation of ATF2 in ATDC5 cells. Cells were incubated with 1 ng/ml TGF-β1 for 0, 0.5, 1, and 2 h. ATF2-p and ATF2-t indicate phosphorylated and total ATF2, respectively. (C) Knockdown of Capn4 impaired PTHrP-mediated cyclin D1 mRNA expression in ATDC5 cells. (D) Knockdown of Capn4 impaired PTHrP-stimulated c-fos mRNA expression in ATDC5 cells. Cells were incubated with 10−8 M PTHrP for 0, 0.5, 1, and 2 h. *, P < 0.05; ***, P < 0.001.