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Model for the role of SCM in Polycomb-induced gene silencing. PHO-SFMBT and SCM-protein X are recruited independently to the PRE. SFMBT and SCM physically interact, and both facilitate either recruitment or retention of PRC2 and PRC1 at the PRE. PRC2 also facilitates recruitment or retention of PRC1 at the PRE. Silencing of the target gene by PRC1 and PRC2 involves histone modifications as well as other mechanisms.
