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Holoenzyme catalytic activity does not require any specific paired region of the 5′ hairpin stem or the 5′ hairpin pocket. Direct primer extension activity assays were performed using extracts of VA13+TERT cells transfected to express the indicated hTR variants. Levels of hTR in the extracts are shown by blot hybridization; note that the hTR variant of lane 8 was slightly underaccumulated in this set.
