FIG. 8.
The RASSF2 promoter is methylated in prostate cancer. (A) RASSF2 promoter methylation in prostate cancer cell lines as determined by MSP. M, methylated; U, unmethylated. (B) RASSF2 promoter methylation expressed as the log10 transformation of the mean PMR in normal prostate (normals), benign prostatic hyperplasia tissue (BPH), and prostate cancer tissue (PCC). Numbers on the right represent the number of samples in each group. (C) RASSF2-positive cells in prostate cancer and normal prostate as determined by immunohistochemical staining. Data were obtained from an average of 10 scored samples. *, P < 0.05 compared to normal prostate. (D) Representative sections of normal prostate and prostate cancer stained for RASSF2 expression.