FIG. 6.

Kidney gross pathology observations at necropsy. The organ appearance of a kidney from an unchallenged baboon of approximately the same age (A) is compared with those from a baboon euthanized 48 h after challenge with 50 ng/kg Stx1 (B) and a baboon euthanized 121.6 h after challenge with 100 ng/kg Stx2 (C). Both toxin-challenged animals had acute renal failure, as judged by reduced urine output and proteinurea and increased plasma BUN and creatinine levels. The gross pathology differences between Stx1 and Stx2 shown are representative of all animals in the high-dose (100 ng/kg Stx1 and 50 ng/kg Stx2) groups.