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. 2010 Mar 22;78(6):2497–2504. doi: 10.1128/IAI.01435-09

FIG. 7.

FIG. 7.

Stx1 and Stx2 challenges result in distinct inflammatory response patterns. Biomarkers were measured in citrated plasma samples after challenge with 10 ng/kg (▴), 50 ng/kg (▪), or 100 ng/kg (•; Stx1 only) toxin, using a multiplex bead-based assay designed for quantification of nonhuman primate antigens. Dose-dependent changes in the proinflammatory mediators IL-6 (A and B), MCP-1 (C and D), and G-CSF (E and F) are shown as means ± SD. (G and H) Neither toxin stimulated production of circulating TNF-α. Paired t tests were used to determine statistical differences from baseline for the following early biomarker changes: IL-6 at 100 ng/kg Stx1 (P < 0.01 at 0.5, 2, 6, and 8 h; P < 0.05 at 4 h; and P < 0.001 at 10 h) and 50 ng/kg Stx1 (P < 0.01 at 0.5 h and P < 0.05 at 4, 6, 8, and 10 h) and G-CSF at 100 ng/kg Stx1 (P ≤ 0.05 at 4, 6, 8, and 10 h).