FIG. 1.
L. pneumophila activates Rip2-dependent pathways in vivo. WT and Rip2-deficient (Rip2−/−) mice in a C57BL/6 background were given a high intranasal dose (1 × 106 CFU) of L. pneumophila ΔflaA. For each group, five mice were sacrificed at days 2, 3, and 5 postinfection as indicated below each graph. (A) BALF from infected mice was assayed for the indicated cytokines by ELISA. Each circle represents data obtained from a single mouse. The lines indicate the mean values calculated from the data for the two groups of mice. *, P < 0.05. (B) Bacterial numbers were determined from lung lysates at the indicated time points. There was no statistical significance between the two groups of mice (P > 0.05).